钟华明

赣南医科大学第一临床医学院

摘要(Abstract)：

阴茎癌是一种少见恶性肿瘤，虽然总体发病率较低，但其对排尿功能、性功能及心理健康的影响明显，晚期或转移性阴茎鳞状细胞癌仍主要依赖铂类化疗，疗效有限且容易产生耐药。因此，探索阴茎癌进展、转移及预后相关的新机制和潜在靶点具有重要意义。近年来，随着低生物量样本检测技术和高通量测序的发展，瘤内细菌逐渐被认为是肿瘤微环境的重要组成部分。研究显示，细菌不仅可存在于肿瘤组织内部，还可呈现肿瘤类型特异性、空间异质性及细胞内定位，并通过调控免疫反应、代谢状态、肿瘤细胞侵袭能力和治疗敏感性等途径影响肿瘤生物学行为。阴茎位于微生物暴露较高的会阴区域，局部炎症、HPV感染及微生态改变均可能参与阴茎癌发生发展。系统总结瘤内细菌在不同肿瘤中的研究进展，有助于为阴茎癌瘤内细菌研究、淋巴结转移风险评估及预后预测提供新的思路。

关键词(KeyWords)：

阴茎癌；瘤内细菌；肿瘤微环境；淋巴结转移；预后

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