王 露 金京春^* 方松鹤^*

延边大学附属医院（延边医院）

摘要(Abstract)：

干燥综合征作为一类慢性系统性自身免疫性疾病，核心病理特征为外分泌腺体的慢性淋巴细胞浸润，其临床症状繁杂且个体差异大，临床诊疗过程中存在确诊延迟、治疗方案选择难等问题，严重干扰患者的正常生活，也大幅降低了患者的长期生存质量。现阶段，免疫学、分子生物学技术的不断革新，推动该病发病机制阐释、诊断体系完善及治疗方案优化等方面的研究持续推进，诸多新发现为临床诊疗突破提供了新方向。本文结合国内外最新研究文献，针对干燥综合征固有免疫与适应性免疫的交叉调控机制、临床常用诊断标准的实践应用差异、新型生物标志物的挖掘验证，以及靶向生物制剂的临床应用效果等核心内容展开系统综述，分析当前领域内研究存在的局限与临床实践面临的挑战，以期为临床医师制定规范化、个体化诊疗方案提供详实参考，并对未来基于发病机制的精准诊疗、个体化管理的发展趋势进行分析与展望。

关键词(KeyWords)：

干燥综合征；自身免疫病；发病机制；诊断标准；靶向治疗；生物标志物

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