蔡可欣 汪友月 徐中华 谢思明^*

暨南大学口腔医学院

摘要(Abstract)：

口腔鳞状细胞癌（OSCC）是头颈部常见恶性肿瘤，侵袭性强、易复发转移且预后差。铁死亡作为铁依赖的脂质过氧化新型调控性细胞死亡方式，与肿瘤发生、耐药及侵袭密切相关。研究表明，OSCC存在铁代谢紊乱和抗氧化系统异常激活，抑制铁死亡可促进肿瘤进展。本文系统综述铁死亡机制、与OSCC耐药关联及靶向干预策略，为探究口腔鳞癌的发病机制与靶向治疗提供全新视角。

关键词(KeyWords)：

口腔鳞状细胞癌；铁死亡；铁代谢；脂质过氧化；靶向治疗；耐药

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